DNA adenine methylase, also known as dam Methyltransferase, is an enzyme that adds a methyl group to the adenine of the sequence 5′-GATC-3′. The figure below represents a double stranded sequence after methylation by dam Methyltransferase. dam Methyltransferase belongs to a large group of enzymes unique to prokaryotes and bacteriophages.
Applications:
– Methylation of genomic DNA
– Labelling of DNA