Reliable gene expression analysis hinges on the immediate stabilization of RNA in biological samples upon harvesting. Gene expression patterns can change due to RNA degradation and transcriptional shifts, making it imperative to halt these changes for accurate results in quantitative gene expression analyses, such as microarray analysis and quantitative RT-PCR. RNA Stabilization Solution offers an advanced way to stabilize and protect RNA within intact tissue samples, eliminating the urgency to process or deep-freeze samples instantly. Once tissues are harvested, they can be directly immersed in the RNA Stabilization Solution, ensuring that the RNA remains intact even during storage or transport at varying temperatures.

The solution is ideal for streamlining workflows, replacing complex and hazard-prone methods such as snap-freezing in liquid nitrogen or immediate sample processing. Tissue samples, once treated, can be preserved in the RNA Stabilization Solution for up to 1 day at 37°C, 1 week at 25°C and 1 month at 4°C. For long-term storage, tissues can be maintained indefinitely at -20°C or colder (-80°C). The solution’s versatility is underscored by its effectiveness across various tissues from vertebrate species, bacterial cultures, tissue culture cells, white blood cells, and even some plants.

RNA Stabilization Solution is compatible with a broad spectrum of RNA isolation methods, including but not limited to TRIzol/NZYol Reagent (Cat. No. MB18501) and standard RNA isolation kits. Moreover, it has been used in downstream applications ranging from mRNA and total RNA isolation to histology, immunocytochemistry, cDNA library construction, Northern blotting, RNA sequencing (RNA-seq), RT-PCR and RT-qPCR, RNA interference (RNAi) studies, MicroRNA (miRNA) analysis and additional techniques. RNA Stabilization Solution is specifically crafted for molecular biology applications. This product is not developed for the diagnosis, prevention, or treatment of any disease.